The Substance is a wild film, but the only thing wilder are these memes about it

The Substance has been pretty much permanently viral since Coralie Fargeat’s body horror hit cinemas. Nobody could quite believe what they’d witnessed, and to be honest – the Demi Moore and Margaret Qualley masterpiece was just so iconic from start to finish with instantly meme-worthy moments it’s literally zero shock to me that the posts about The Substance have been utterly hilarious. Since the memes are coming thick and fast, here’s a rundown of all the funniest The Substance posts from Twitter.

1. They were sick of Elisabeth Sparkle

the substance customer service seeing demi call again pic.twitter.com/i4vZxYu7iR

— cj- (@cjnieI) October 4, 2024

2. It gives me that BUZZ

https://twitter.com/aynchilada/status/1841950427631517947

3. Heavenly teeth fair play

Margaret Qualley in THE SUBSTANCE making me realize how much I’ve missed actors having natural teeth instead of veneers. pic.twitter.com/qiz8Lp6Qml

— Jillian🫧 (@JillianChili) October 5, 2024

4. Justice for her imo 

everyone in my showing of The Substance laughing at Monstruo Elisasue pic.twitter.com/HG1PbsuETc

— 🐇 (@shadwheart) October 7, 2024

5. It was giving D.I.Y. SOS

The Substance is about how beautiful women can also do home renovations

— Isle McElroy (@isle_mcelroy) October 3, 2024

6. Pure holy cinema

me watching the last scene in The Substance pic.twitter.com/FCj2eothHX

— The Jenna Cha Show (@kale_satan) October 6, 2024

7. Just audibly gasped and then gagged at my desk

the substance is like if they made this into a feature length movie pic.twitter.com/hFoJG4tQUy

— daddy khakipants (@pos_pisces) October 6, 2024

8. Just fell to my knees

thinking about how The Substance floor is The Shining floor but the red part of the pattern split into two pic.twitter.com/gDhsMSavXY

— Wendell (@RhodeToLove) October 7, 2024

9. They were so real for that

I’ll never forget the person in my theater who whispered “that’s the substance” when she first unboxed the substance

— small potatoes (@spinachleafs) October 7, 2024

10. Oh pack this in I am cackling

He took the substance pic.twitter.com/FCtnbBlEZ4

— rev (@whyrev) September 30, 2024

11. Life imitates art it seems

The Substance (2024) – Dir. Coralie Fargeat pic.twitter.com/Gp4ragIl3d

— 👹👹 ₕₒₜ Gᵢᵣₗ ₑₗ 👹👹 (@elly_forever) October 7, 2024

12. I felt uproarious it must be said

This was me during The Substance btw pic.twitter.com/9bWXZaTVAd

— Helluva Bottom Carter (@bingomilf) October 8, 2024

13. Oh I’m slurping

i know the food packets in the substance were taken intravenously but i imagined it to taste like this pic.twitter.com/a9qWPWU4rJ

— ✞ nessie ✞ (@swankisses) October 5, 2024

14. Actually funny Twitter accounts for a film we are blessed

they gave The Substance to a grape https://t.co/qVBmuV0cQ9

— The Substance (@TryTheSubstance) October 5, 2024

15. Bonafide scene stealer

Demi Moore’s coat in The Substance is the best performance by a coat in a motion picture since JLo’s coat in Hustlers pic.twitter.com/7ryrqgovqy

— Wendell (@RhodeToLove) October 1, 2024

16. The fact Demi Moore put this tweet on her Instagram 

omg the moon took the substance https://t.co/xMRey4nTrr

— toni collette stan account (@HarryPhillips15) September 30, 2024

17. The gorgeous and kind Sue

sue is so kind💖 pic.twitter.com/xOlhicZAHY

— bethany (@fiImgal) October 2, 2024

18. Need these dogs in the inevitable sequel

there’s been a slight misuse of The Substance https://t.co/RSa6t06SBj

— The Substance (@TryTheSubstance) October 1, 2024

19. I will never forgive this film for what it did to my Glenn Close

The Substance pic.twitter.com/ZPd2dgjBro

— Katya (@katya_zamo) September 30, 2024

20. Pack this in right this second 

Moo Deng is what came out of Fiona the hippo when she took The Substance

— alyssa (@alyssaraetho) September 25, 2024

21. We’ll leave this here cause I don’t think it gets better than this

The Substance (2024) pic.twitter.com/l8qkuEeUrY

— Lee (@LeeDawsonPT) September 25, 2024

The Substance starring Demi Moore and Margaret Qualley is in cinemas now. For more like this on The Substance plus all the latest news, drops, quizzes and memes, like The Tab on Facebook. 

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