Scientists make the world’s first male contraceptive pill, and reveal major breakthrough

There has been a major breakthrough in the world’s first male contraceptive pill, as it’s been found to be safe in the first-ever human trial.

YCT-529 is an experimental non-hormonal male contraceptive pill developed by YourChoice Therapeutics, which prevents unwanted pregnancy by temporarily stopping sperm production.

The first phase of human clinical trials have been completed, which assessed the tablet’s safety for humans. Sixteen male volunteers aged 32 to 59 were given oral doses of 10, 30, 90 or 180 mg of YCT-529.

Results published in Communications Medicine on 22nd July, 2025, reveal that single doses of YCT-529 up to 180 mg of YCT-529 “had no effects on heart rate, hormone levels, sexual desire or mood”.

“Overall, YCT-529 was well tolerated in this single ascending dose study, which is a substantial requirement in contraceptive development,” the researchers said.

Credit: Canva

They added: “Since nearly half of all pregnancies in the US and worldwide are unintended, there is a critical need for additional contraceptive options for men and women.”

This huge breakthrough means we are one step closer to a safe and viable contraception option for men finally going on the market. However, it will still be a long way off as many more trials need to be done.

Speaking on the Today programme, Professor Alan Pacey, an andrologist at the University of Manchester, said it is an “exciting step forward,” but the pill now needs to be tested in a real-life setting to see if it actually prevents pregnancy successfully.

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“It takes three months to produce sperm from start to finish and so if you were to start taking any pill, not just this one, you would need to have the sperm that are currently on the production line to be moved from the system,” he explained. “So, there will be a lag between starting to take the pill and it having its full contraceptive effects.”

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Featured image by: Canva