Ozempic vs Mounjaro: The difference between the celeb weight loss jabs they’re all using

Injectable weight loss drugs are everywhere right now. From TikTok trends to red carpet reveals, celebs and influencers are lining up for them. Ozempic and Mounjaro were both made to treat type 2 diabetes. Now they’re being used off-label—or legally in some cases—to help shed weight fast.

But there are real differences between them.

Only Mounjaro is approved for weight loss in the UK

Mounjaro is the only injectable weight loss drug officially approved in the UK.

Mounjaro can be prescribed here for obesity and weight-related conditions. It contains tirzepatide and is licensed for use beyond diabetes.

Ozempic, on the other hand, contains semaglutide and is approved in the UK only for type 2 diabetes—not weight loss. But some private clinics still hand it out.

According to ASDA’s Online Doctor, Mounjaro and Ozempic do similar things in different ways.

So, what’s the difference between the two?

The GLP-1s like Ozempic, Mounjaro, Wegovy, may interfere with dopamine, the brain chemical that controls feelings of reward and pleasure, along with downstream chemicals for mood regulation.

What does this mean?? Well if you’re at risk for mood disorders, this is a whooper! This… pic.twitter.com/uYjgK8TCr2

— Rupali Chadha, M.D.🩺 (@RupaliChadhaMD) April 26, 2025

Basically, Mounjaro mimics two hormones that reduce appetite. It helps people feel full and stay full longer. Whereas, Ozempic mainly helps the body use insulin more effectively, which also cuts hunger.

They’re both weekly injections and cause similar side effects, nausea, tiredness, constipation, and vomiting. But Mounjaro has a higher maximum dose: 15mg versus Ozempic’s 2mg. That means stronger effects, and sometimes stronger side effects too.

Celebrities have shared their experiences

🚨🇺🇸| SCHUMER PRAISES MOUNJARO SUCCESS

Amy Schumer shares on Instagram that Mounjaro worked wonders for her weight loss and perimenopause symptoms, unlike Ozempic, which left her bedridden with nausea. The comedian lost 30 lbs on Ozempic but loves Mounjaro’s energy boost. pic.twitter.com/6SZJAnsPyX

— Leil (@LeilIdeas) March 23, 2025

Plenty of celebs have jumped on the jab trend, and many haven’t had an easy ride.

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Gemma Collins used Mounjaro and lost around two stone. But she wasn’t happy with how it changed her face. “I’ve always had a fuller face,” she said. “But this just isn’t right. I want to look natural still.”

Jeremy Clarkson tried Ozempic and had a rough time. Writing in The Times, he said it made him vomit and gave him no joy around food. “That’s not living. That’s existing,” he said. He later switched to Mounjaro and found it easier, but still frustrating.

Amy Schumer had an even worse experience. “I was, like, bedridden,” she said about using Ozempic. “I was vomiting and had no energy.” She later said Mounjaro worked better for her, alongside hormone therapy for perimenopause.

So, which one is safe to try?

Well, both Ozempic and Mounjaro come with serious risks, and the effects don’t last unless you stay on them. People tend to regain most of the weight, and lose health benefits, after stopping treatment.

So, while these drugs are reshaping diet culture and celebrity beauty standards, they aren’t a fix-all. And they definitely aren’t casual.

Always speak to a doctor before considering weight loss medication.

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